Published on : Oct 07, 2019
Albany, New York, October 7, 2019: Alpha synuclein is involved in transmitter regulation at the time of synapse and is found throughout the body. It is abundantly present on brain and is encoded by SNCA gene. It restricts synaptic vesicles mobility, thereby attenuating recycling of synaptic vesicles and release of neurotransmitters.
Clinical diagnosis of Parkinson’s disease is made at very later stage where nerve cells have already undergone serious damage. Parkinson’s disease results in irreversible change in body which needs to be stopped with early stage diagnosis. Alpha synuclein is important ingredient of lewy bodies that form toxic aggregates that accumulate to result in Parkinson’s disease. Presence of alpha synuclein gives enormous benefits to treatment strategies that are designed to halts progression of Parkinson’s disease by preventing accumulation of such toxic aggregates. Popularity of alpha synuclein as a molecular biomarker propels alpha synuclein market.
An intelligence report titled, “Alpha Synuclein-Pipeline Review, H2 2019” is the source of all the stated insights. This report is the latest addition to Market Research Hub’s ever growing repository
Glucose levels regulation
Alpha synuclein can be segregated structurally into three domains that incudes central domain that binds amyloid, alpha helix that binds lipid and C terminal acidic tail. Alpha helix structure associated with phospholipids can be the location of alpha synuclein from where it contributes significantly in various cellular locations .NAC is the core region of alpha synuclein and helps in aggregation and formation of fibril by forming cross beta structures.
Apoptosis suppression in dopaminergic neurons by reduction in activities of protein kinase C is one of the primary functions performed by alpha synuclein. It interacts with secretory granules that contain insulin and decrease insulin secretion to regulate the glucose levels. Alpha synuclein maintains levels of polyunsaturated fatty acids and acts as antioxidant to prevent unsaturated lipids oxidation into vesicles.
Alpha synuclein accumulate in brain nerve cells of Parkinson disease effected person causing inflammation and cell death which triggers difficulties in functionalities such as digestion, sleep, circulation and movement. Researches indicate towards inhibiting alpha synuclein aggregation to cure Parkinson’s disease.
Alpha Synuclein pipeline review: Report Synopsis
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Alpha Synuclein pipeline review: Research Methodology
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