Published on : Sep 20, 2019
Albany, New York, September 20, 2019: Bcl-2-like 1 is a human gene that encodes protein. The Bcl2 family proteins drive the survival of multiple myeloma cells present in human body. When members of this BCL-2 family form hetero- or homodimers, they serve as anti- or pro-apoptotic regulators known for involvement in cellular activity.
Intelligence report, titled, “Bcl 2 Like Protein 1 – Pipeline Review, H2 2019” is the source of the stated insights. The report is the recent addition to the growing repository of Market Research Hub (MRH).
Bcl2 protein can promote cell death
The protein encoded by Bcl-2-Like 1 gene regulates outer mitochondrial membrane channel (VDAC) opening as it is located inside the membrane. Thus, it gets involved in critical steps of cell death pathway by binding to the voltage-dependent anion channel and blocking it to prevent release of caspase activator from mitrochondria.
Presence of two alternatively sliced transcript variants, both encoding different isoforms are known to exist. Bcl-xl is the longer isoform and Bcl-xS is the shorter one. Bcl-xL is involved in regulation of presynaptic plasticity that includes neurotransmitter release and recovery, and number of synaptic vesicle clusters. Isoform Bcl-xS is involved in promoting apoptosis.
Size reduction of gastric cancer tumor becomes instrumental
A study was conducted on Gastric Cancer patients from Asia to discover the relevance of Bcl2 family protein in drugs. A Bcl-2-L1 targeted drug was found effective in size reduction of gastric cancer tumors when applied in combination of irinotecan therapy. Of late, Bcl2-like protein have been known to shield cells from non-apoptotic death by warding off exhaustive autophagy.
Bcl 2 Like Protein 1 – Pipeline Review: Report Synopsis
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