Intercellular Adhesion Molecule 1 linked with Immune Response and blood Leucocytes Circulation


Published on : Sep 20, 2019

Albany, New York, September 20, 2019: Intercellular Adhesion Molecule (ICAM) is a part of immunoglobulin superfamily. Some important events taking place in human body such as inflammation and immune responses take place with help of ICAMs. Further, the ICAM family is divided into 5 members and ICAM 1 is one of them. ICAM 1is expressed by cell types such as leucocytes and endothelial cells.ICAM-1 is known to be important in stabilizing cell interactions. Its association with immune responses implies that there is possibility of ICAM-1 functioning in signal transduction.

All the insights stated here are from the intelligence report, titled, “Intercellular Adhesion Molecule 1- Pipeline Review, H2 2019” the latest addition to the Market Research Hub’s (MRH) ever-growing repository

 Several Cytokines such as tumor necrosis factor-alpha and interleukin-1 can induce ICAM-1 in cell-specific manner. Membrane-bound integrin receptors LFA-1 and MAC-1 on leucocytes, rhinoviruses, the matrix factor hyaluronan, CD43, the soluble molecule fibrinogen and Plasmodium falciparum malaria-infected erythrocytes are its ligands. Various efferent and afferent immune responses that need intercellular collaboration and contact such as T helper responses, antigen induced T cell proliferation and cell-mediated cytotoxicity are facilitated by ICAM 1.

ICAM1 is known to be involved in blood leukocytes circulation and infiltration of cytolytic effector leucocytes into tumors. According to a report, in renal cell carcinoma, down-regulated expression of vascular ICAM-1 on tumor-infiltrating endothelial cells is observed, which is obtained from flow cytometric analysis of Tumor EC and EC of a healthy tissue.

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