Published on : Sep 09, 2019
Albany, New York, September 9, 2019: Microscopic polyangiitis is a systemic necrotizing vasculitis characterized by inflammation of the blood vessels that can derail blood flow and have toll on vital tissues and organs. Further, MPA tends to target small-to medium-sized blood vessels that involve the lungs, kidney, skin, nerves and joints. Prominently, diagnosis and treatment become imperative to keep kidney and respiratory damage at bay.
These insights are according to the intelligence report, titled, “Microscopic Polyangiitis (MPA)-Pipeline Review, H2 2019,” which has been freshly added to Market Research Hub’s (MRH) overarching armamentarium.
Even though cause of MPA is yet to be fully comprehended by researchers, they infer an infection may propel the inflammatory process in motion in MPA. Nevertheless, vasculitis has been classified as an autoimmune disorder.
Patients who have unexplained combinations of weight loss, fever, alveolar hemorrhage, arthralgias, new-onset nephritic syndrome are suspected with microscopic polyangiitis (MPA). Although x-rays and laboratory tests are done, a biopsy is sought to confirm the diagnosis. Renal biopsy may spot focal segmental pauci-immune necrotizing glomerulonephritis with fibrinoid necrosis of the glomerular capillary wall, thereby leading to formation of cellular crescents.
Some of the prominent tests comprises of C-reactive protein, CBC, serum creatinine, ESR, urinalysis and tests for antineutrophil cytoplasmic antibodies (ANCA).
Treatment is usually based on an array of factors, including organ involvement and disease severity. Further, corticosteroids including prednisone used in combination with other medication is second to none in the treatment of microscopic polyangiitis (MPA).
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