Genetically Advanced Models deliver Excellent Disease Risk Stratification

Published on : Dec 12, 2019

Post-Polycythemia Vera Myelofibrosis involves myeloid cells that undergo clonal proliferation that results in different conditions including extramedullary hematopoiesis, constitutional symptoms such as night sweats, fatigue, fever and weight loss, and cytopenia. Bone marrow fibrosis and risk of acute myeloid leukemia are the other symptoms. Risk factors including advanced age, greater disease burden and longer duration of disease predict the fibrotic transformation. The prognosis of Post-Polycythemia Vera Myelofibrosis varies between few months and several years. Accurate prognostication is presumed to be essential for using curative therapies that exist with high risk that include allogeneic stem cell transplant.

An intelligence report titled, “Post-Polycythemia Vera Myelofibrosis (PPV-MF)-Pipeline Review, H2 2019” is the source of all the stated insights. This report is the latest addition to Market Research Hub’s ever growing repository.

Different factors including laboratory data, genetic findings and morphological structure of bone marrow are cumulatively studies to determine the diagnostic criteria for Post-Polycythemia Vera Myelofibrosis. International organizations such as International Working Group-Myeloproliferative Neoplasms Research and Treatment (IWG-MRT) have set standards for diagnosis of Post-Polycythemia Vera Myelofibrosis.

Different drugs including pegylated IFN- ?, ruxolutinib and busulfan are considered to be the second line of therapy for Polycythemia Vera. Models that are molecularly and genetically enhanced have been proposed for Post-Polycythemia Vera Myelofibrosis and are accepted as excellent tool for disease risk stratification. The existing models fall short in terms of representation of dynamic nature of MF and patients comorbidities. Relevant models are being developed to reflect pathology of the underlying disease and to identify therapies that have the potential to deter the outcome of disease.

Post-Polycythemia Vera Myelofibrosis pipeline review H2 2019: Report Synopsis

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Post-Polycythemia Vera Myelofibrosis pipeline review H2 2019: Research Methodology

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