RNA - Targeted Small Molecules: Prokaryotic Ribosomal RNA is the target of Commercial Antibiotics


Published on : Sep 23, 2019

Albany, New York, September 23, 2019: RNA molecules are essential for gene regulation and cellular information transfer. They often mediate the biology of disease in effected and healthy cells. There are messenger and non-coding RNAs that contain some highly structured elements. These RNAs are targeted with small molecules to create opportunities of therapeutically modulating cellular processes.

Small molecules are the latest RNA-focused therapeutics. Their advantages over RNA includes better stability, easier entry into cells and oral administration. Currently, there exists only a single class of designed molecules that is clinically used to target RNA molecules. However, the identified number of small molecule RNA ligands keeps growing, keeping a burgeoning interest in this field.

Prokaryotic ribosomal RNA is important as it is the target of several commercially used antibiotics. There has been growth in understanding of multitude of RNA molecules that include long non-coding RNA, micro RNA, piwiRNA, anti-sense RNA , circular RNA and short hairpin RNA.

These insights are according to the intelligence report, titled, “RNA-Targeted Small Molecules 2019: a landscape analysis of companies, technologies, targets, investors and partners from an industry perspective,” which has been freshly added to Market Research Hub’s (MRH) over-arching repository

Oligonucleotides suffer from poor pharmacodynamics properties

Oligonucleotides are the known RNA targeting agents. They are efficient but suffer from poor pharmacokinetic and pharmacodynamics properties. Numerous synthetic small-molecule ligands have been identified as better alternatives.

Prokaryotic ribosomal RNA is important as it is the target of several commercially used antibiotics. For medical use, there has been growth in understanding of multitude of RNA molecules that include long non-coding RNA, micro RNA, piwiRNA, anti-sense RNA , circular RNA and short hairpin RNA.

Advancements in the knowledge of RNA’s diversity, structural and functional knowledge have pulled them into lime light as major drug target. RNA performs various roles in transcription regulation, catalysis, protein function, protein transport, regulation of translation, RNA splicing and peptide bond formation. RNA is the newly identified potential target in multitude of diseases such as cancer and bacterial/viral infections.

Standing challenges in developing methods to obtain bioactive compounds to moderate RNA targets and companion methods that are capable to validate their direct effects in cells. 

RNA-Targeted Small Molecules 2019: a landscape analysis: Report Synopsis

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RNA-Targeted Small Molecules 2019: a landscape analysis: Research Methodology

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