Published on : Oct 07, 2019
Albany, New York, October 7, 2019: Smoothened homolog interacts with patched protein as a receptor coupled with G protein. These patched proteins act as hedge dog protein receptor. The hedge dog protein activates encoded protein which induces signals to other proteins.
Hedgehog pathway maintains tumor by oncogenic transformation and hedgehog proteins constitutes proteins responsible for controlling various activities performed at cellular level that include cell growth, differentiation and survival. Smoothened homolog is inhibited by PITCH in Hh ligand’s absence whereas Hh presence activates smoothened homolog by releasing it from PITCH initiated suppression. This triggers intracellular events that stabilize zinc-finger transcription factors ? GL1, GL2 and GL3.
Hh pathway along with its aberrations in cancer has potential to effect the designs of anticancer therapies. Cyclopamine acts as Hh inhibitor and binds to smoothened homolog to deactivate it. Vismodegib is a food and drug administration approved smoothened homolog antagonist that aids in advanced metastatic basal cell carcinoma treatment.
An intelligence report titled, “Smoothened Homolog-Pipeline Review, H2 2019” is the source of all the stated insights. This report is the latest addition to Market Research Hub’s ever growing repository.
Hedgedog signaling pathway aids cancer-leading activities
Hepatocellular carcinoma leads to great proportion of cancer related deaths. Hepatocarcinogenesis involves sonic hedgehog signaling pathway that participates in various cancer-leading activities that include carcinogenesis, invasiveness, cancer stem cell maintenance, progression and reoccurrence. Pitch induced smoothened homolog inhibition initiates the signal transduction process transcription factors associated with glioma. Molecules associated with Shh pathway that includes smoothened homolog, Ptch-1 and Gli are over expressed in patients suffering from Hepatocellular carcinoma. Inhibition in Shh signaling pathway activities aid Hepatocellular carcinoma in multiple ways including increased radio sensitivity, reduced growth and enhanced chemotherapy impact.
Smoothened homolog pipeline review: Report Synopsis
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Smoothened homolog pipeline review: Research Methodology
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