The Global Market for Pain Management Drugs and Devices

The Global Market for Pain Management Drugs and Devices

Aug 2017 BCC Research Healthcare251 Pages Price :
$ $4950

The global market for pain management will grow from nearly $36.1 billion in 2017 to $52.0 billion by 2022, with a compound annual growth rate (CAGR) of 7.6% for the period of 2017-2022.
The pharmaceutical segment will grow from $32.3 billion in 2017 to $47.6 billion by 2022, rising at a CAGR of 8.1%.
The device segment is expected to increase from $3.7 billion in 2017 to nearly $4.4 billion by 2022 with a CAGR of 3.3%.

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Table of Contents
Chapter 1: Introduction 1
Study Goals and Objectives-1
Reasons for Doing This Study -1
Scope of Report -1
Methodology and Information Sources -3
Geographic Breakdown- 3
Analysts Credentials -7
Related BCC Research Reports7
Chapter 2: Summary and Highlights 9
Overview- 9
Summary of the Major Markets-9
Market Trends -11
Undertreatment Issues -11
Professional Pain Treatment Issues -11
Access to Care -12
FDA Requirements for Approval of Pain Therapies- 12
Drug Delivery Systems -12
Chapter 3: Market and Technology Background 14
History of Pain and Pain Treatment 14
The Perception of Pain 15
Types of Pain -16
Acute Pain- 16
Chronic Pain-16
Assessment of Pain 17
Subjective - 17
Objective - 17
How Pain is Diagnosed - 18
How Pain is Treated - 19
Demographics and Aging Populations - 25
Global Demographic Overview- 25
Gender and Pain - 30
Other Influences Determining How Pain is Felt Among Individuals - 33
Pain Management Procedures: Steroids, Endoscopy, Fluoroscopy - 34
Alternative Methods of Pain Management - 35
Growing Trend in Cannabis Treatment for Pain - 37
Physical Pain Treatment Modalities- 42
Acupuncture/Acupressure - 42
Ice (Cryotherapy) - 44
Joint Mobilization - 44
Manipulation - 44
Massage - 44
Traction - 45
Radiation Therapy - 45
Radio-Frequency Neuroablation, Epiduroscopy - 45
Surgery - 46
Whirlpool Bath (Thermotherapy) - 46
Psychological Pain Therapies - 47
Biofeedback - 47
Hypnosis - 48
Behavior Modification/Operant Conditioning - 48
Relaxation and Stress Management Training- 48
Imagery - 49
Autogenic Training - 49
Psychosocial Interventions - 49
Distraction and Reframing- 50
Tracking the Development of Complementary and Alternative Pain Control Methods - 50
Pain Management Services and Organizations- 53
Home Care - 53
Hospice - 54
Hospitals - 59
Pain Clinics - 59
Skilled Nursing Facilities - 69
Chapter 4: Industry Trends - 71
Overview - 71
Undertreatment Issues - 71
Treatment of Pain and Issues Facing the Professional Segment- 74
Prescription Drug Monitoring Programs - 78
Access to Care - 86
Managed Care Pain Management Issues - 118
FDA Approval of Pain Therapies - 118
FDA Approval of Pain Devices - 119
Risk Evaluation and Mitigation Strategy (REMS) - 122
Acetaminophen and FDA Changes - 126
Codeine in Cough and Cold Medications - 126
NSAIDs Linked to Increased Risk of Heart Attack or Stroke - 127
Drug Delivery Systems - 128
Chapter 5: Treating Pain: Markets by Product Type - 132
Overview - 132
Pharmaceutical Pain Management - 132
Prescription Pain Management Products- 132
Total Market - 135
Narcotic Analgesics- 137
Non-narcotic Analgesics - 143
Antimigraine Agents - 145
Anesthetics - 148
Other Drug Classes - 150
Pain Management Devices- 151
Pain Management Device Market - 152
Total Market - 152
Stimulation Therapy - 153
Combination Pain Management Devices - 158
Chapter 6: Market Breakdown by Application - 162
Pain Management by Application - 162
Surgical Pain Management - 164
Orthopedic/Musculoskeletal Pain Management - 168
Fibromyalgia Pain - 172
Cancer Pain Management - 173
Neuropathic Pain - 178
HIV/AIDS Related Pain - 179
Burn Pain - 180
Dental Pain - 184
Chapter 7: Market Breakdown by Region - 187
Global Health Indicators - 187
Health Expenditures and GDP Review - 187
Average Length of Stay - 188
Public Healthcare Systems Around the World - 189
Markets by Global Region - 191
North America - 193
Europe, Middle East, Africa (EMEA) - 194
Asia-Pacific- 194
Latin America - 195
Chapter 8: Industry Developments - 197
Timeline of Significant Industry Events and Developments - 197
Pharmaceutical Pipeline- 200
Pain Device Clinical Trials - 211
Patent Analysis - 213
Patent Review by Year - 214
Patent Review by Type - 215
Patent Review by Company- 217
Patent Review by Country - 217
Patent Review by Assignee- 218
Drug Patents for Selected Therapies - 221
The Brand/Generic Market Split - 227
Future of Pain Research - 228
Pain Research: Pediatric Populations - 231
Patient Outcomes Research - 232
Selected Pain-related Acquisitions and Alliances - 232
Chapter 9: Analysis of Market Opportunities - 236
Total Pain Management Market - 237
Markets by Type - 238
Markets by Application - 239
Markets by Global Region - 241
Chapter 10: Company Profiles - 244
Appendix A: Terminology and Sources of Information - 264
Pain Management Pharmaceutical Manufacturers and Developers - 265
U.S. Pain Societies and Associations - 269
International Associations and Organizations - 270
About BCC Research - 272
About BCC Research- 273
BCC Membership - 273
BCC Custom Research - 273

List of Table

List of Tables
Summary Table: Global Market for Pain Management, by Major Segment, Through 2022 ($ Millions) .. 10
Table 1 Objective Signs of Pain - 17
Table 2 Global Population Growth, by Select Country, 2015 and 2020 (Millions) - 26
Table 3 Global Population Growth, by Age Group, Through 2050 (Millions) - 28
Table 4 Global Life Expectancy at Birth, by Select Country, 1980-2020 (Years) - 29
Table 5 Pain by Select Category and Gender in the Age 18+ U.S. Population,* 1997-2010 (Thousands) .. 31
Table 6 U.S. Medical Marijuana Programs, by State - 38
Table 7 Effectiveness of Fibromyalgia Treatments: Cannabis vs. Pharmaceutical Therapies, 2014 (%) ... 42
Table 8 Use of Complementary and Alternative Medicine Among U.S. Adults, by Type of Therapy, 2002
2015 (Thousands) - 51
Table 9 Percentage of U.S. Hospice Patients, by Gender and Age Group, 20092014 - 55
(%) - 55
Table 10 Percentage of Hospice Admissions, by Primary Diagnosis, 20092014 (% of Total) - 57
Table 11 NHPCO Committees - 58
Table 12 Definition of Pain Clinics- 60
Table 13 Desirable Characteristics of Pain Clinics, by Type - 61
Table 14 Registered Pain Clinics in the United States, by Top Metro Area, 2016 (Number) - 64
Table 15 Registered Pain Clinics, by Country (Number) - 68
Table 16 Availability of Education in Pain Management, by Select Region/Country - 77
Table 17 Agency Responsible for PDMP in Each State - 78
Table 18 Benefits of Prescription Monitoring Programs for Medical Boards - 79
Table 19 Drugs Monitored by PDMPS, as of June 2017 - 79
Table 20 States with Electronic Prescription Monitoring Programs, as of June 2017 - 80
Table 21 Nurse Continuing Education Requirements for Pain Management, by Requiring State - 83
Table 22 WHO List of Essential Medicines for Adult Pain Management - 91
Table 23 Availability of Injectable Morphine, by Region/Country - 92
Table 24 Availability of Oral Morphine in Hospice-Type Settings, by Region/Country - 93
Table 25 FDA Analgesia/Anesthesia Drug Shortages, June 2017- 96
Table 26 Parts 862892 of 21 CFR - 121
Table 27 List of Extended-Release and Long-Acting Opioid Products Subject to Opioid REMS, by Brand
Name Product, May 2017 - 123
Table 28 List of Extended-Release and Long-Acting Opioid Products Subject to Opioid REMS, by Generic
Product, May 2017 - 124
Table 29 List of Products Subject to the TIRF REMS Access Program, 20112016 - 125
Table 30 List of NSAIDs - 127
Table 31 Advantages of Iontophoretic Drug Delivery - 129
Table 32 FDA Applications/Approvals, Jan. 2010 Through Jan. 2017 - 133
Table 33 Global Market for Prescription Pain Management Pharmaceuticals, by Product, Through 2022
($ Millions) - 136
Table 34 Most Commonly Used General Anesthetic Agents - 148
Table 35 Global Market for Pain Management Devices, by Technology Type, Through 2022 ($ Millions)
- 152
Table 36 Global Market for Pain Management, by Application, Through 2022 ($ Millions) - 163
Table 37 Global Market for Surgical Pain Management, by Product Type, Through 2022 ($ Millions) ... 165
Table 38 Birth Rates and Births, by Country, 2016 and 2025 (Thousands) - 167
Table 39 Global Market for Orthopedic/Musculoskeletal Pain Management, by Product Type, Through
2022 ($ Millions) - 168
Table 40 Global Market for Migraine/Headache Pain Management, by Product Type, Through 2022 ($
Millions) - 172
Table 41 Global Market for Fibromyalgia Pain Management, by Product Type, Through 2022 ($ Millions)
- 173
Table 42 Cancer Pain Medication - 177
Table 43 Global Market for Cancer Pain Management, by Product Type, Through 2022 ($ Millions) - 177
Table 44 Global Market for Neuropathic Pain Management, by Product Type, Through 2022 ($ Millions)
- 179
Table 45 Global Market for HIV/AIDS Pain Management, by Product Type, Through 2022 ($ Millions) . 180
Table 46 Global Market for Burn Pain Management, by Product Type, Through 2022 ($ Millions) - 184
Table 47 Global Market for Dental Pain Management, Through 2022 ($ Millions) - 185
Table 48 Health Expenditures as a Percentage of GDP, by Select Country, 19802015 (%) - 187
Table 49 Average Hospital Length of Stay, by Select Country, 19702015 (Days) - 189
Table 50 World Health Organization Ranking of Healthcare Systems, 2000 - 190
Table 51 Major Countries, by Region - 191
Table 52 Global Market for Pain Management, by Region, Through 2022 ($ Millions) - 192
Table 53 North American Market for Pain Management, by Application, Through 2022 ($ Millions) - 193
Table 54 EMEA Market for Pain Management, by Application, Through 2022 ($ Millions) - 194
Table 55 Asia-Pacific Market for Pain Management, by Application, Through 2022 ($ Millions) - 195
Table 56 Latin America Market for Pain Management, by Application, Through 2022 ($ Millions) - 195
Table 57 Select Pain Management Drug Pipelines - 201
Table 58 Selected Pain Management Device Trials - 212
Table 59 U.S. Patents on Pain Treatments, Issued, by Year, Jan. 2000 Through March 2017 (Number) . 214
Table 60 Number of U.S. Patents on Pain Technologies, by Abstract Description - 216
Table 61 U.S. Patents on Recent Pain Technologies, March 21, 2017-April 18, 2017 - 218
Table 62 U.S. Patent Expiration Dates for Select Pain Drugs - 222
Table 63 First Time Prescription Generic Pain Management and Approvals, April 2005-June 2017 ....... 224
Table 64 Pain or Pain-related Clinical Trials, by Region, 2017 - 230
Table 65 Market Opportunities for Pain Management Treatments, Through 2022 - 236
Table 66 Global Market for Pain Management, by Major Type, Through 2022 ($ Millions) - 238
Table 67 Global Market for Pain Management, by Application, Through 2022 ($ Millions) - 240
Table 68 Global Market for Pain Management, by Region, Through 2022 ($ Millions) - 241
Table 69 Abbott Laboratories Financials, Through 2016 ($ Millions) - 245
Table 70 AbbVie Financials, Through 2016 ($ Millions) - 246
Table 71 Allergan Financials, Through 2016 ($ Millions) - 246
Table 72 AstraZeneca Financials, Through 2016 ($ Millions) - 248
Table 73 Boston Scientific Financials, Through 2016 ($ Millions) - 249
Table 74 Depomed Financials, Through 2016 ($ Millions) - 250
Table 75 DJO Global financials, Through 2016 ($ Millions) - 251
Table 76 Eli Lilly & Co. Financials, Through 2016 ($ Millions) - 252
Table 77 Endo International Financials, Through 2016 ($ Millions) - 253
Table 78 GlaxoSmithKline Financials, Through 2016 ($ Millions) - 254
Table 79 Grnenthal Financials, Through 2016 ($ Millions) - 255
Table 80 Hisamitsu Pharmaceutical financials, Through Fiscal 2017 ($ Millions) - 256
Table 81 Johnson & Johnson Financials, Through 2016 ($ Millions) - 257
Table 82 Medtronic Financials, Through Fiscal Year 2016 ($ Millions) - 258
Table 83 Novartis Financials, Through 2016 ($ Millions) - 260
Table 84 Pfizer Financials, Through 2016 ($ Millions) - 261
Table 85 Glossary of terms used in Pain Management Drug and Device Markets - 264
Table 86 Pain Management Pharmaceutical Manufacturers and Developers - 265
Table 87 U.S. Pain Societies and Associations - 269
Table 88 International Associations and Organizations- 270

List of Chart

List of Figures
Summary Figure: Global Market for Pain Management, by Major Segment, 20142022 ($ Millions) - 10
Figure 1 Pain Management Techniques- 19
Figure 2 Global Population, by Select Country, 2015 and 2020 (Millions) - 27
Figure 3 Global Population Growth, by Age Group, 20002050 (Millions) - 28
Figure 4 Global Life Expectancy at Birth, 1980-2020 (Years) - 30
Figure 5 Pain by Select Category and Gender in the 18+ U.S. Population,* 1997-2010 (%) - 32
Figure 6 Use of Complementary and Alternative Medicine Among U.S. Adults, by Type of Therapy,
20022015 (Thousands) - 52
Figure 7 Annual Number of U.S. Hospice Patients, 20092014 - 54
Figure 8 Percentage of U.S. Hospice Patients, by Gender, 2014 (%) - 55
Figure 9 Percentage of U.S. Hospice Patients, by Age Group, 2014 (%) - 56
Figure10 Distribution of Causes of Mortality and Potential Need for Palliative Care (Millions) - 89
Figure 11 Distribution of Narcotic Drug Consumption, by Country (All Narcotic Types) (%) - 90
Figure 12 Distribution of Morphine Consumption by Region/Country, 2015 (%) - 94
Figure 13 Obstacles to Availability of Opioids for Medical Needs (Number) - 95
Figure 14 Global Market for Prescription Pain Management Pharmaceuticals, by Product, 20142022 ($
Millions) - 137
Figure 15 Global Market Distribution for Narcotic Analgesics, by Ingredient*, 2017 (%) - 143
Figure 16 Global Market Distribution for Non-Narcotic Analgesics, by Ingredient*, 2017 (%) - 145
Figure 17 Global Market Distribution for Antimigraine Agents, by Ingredient*, 2017 (%) - 147
Figure 18 Global Market Distribution for Anesthetics, by Ingredient*, 2017 (%) - 150
Figure 19 Global Market for Pain Management Devices, by Technology Type, 20142022 ($ Millions) . 153
Figure 20 Global Market for Pain Management, by Application, 20142022 ($ Millions) - 164
Figure 21 Global Market for Surgical Pain Management, by Product Type, 20142022 ($ Millions) - 166
Figure 22 Births, by Country, 2016 and 2025 - 167
Figure 23 Arthritis Impact, Global Prevalence, by Year, 20002050 - 169
Figure 24 Global Cancer Mortality by Select Country per 100,000 Population, 19602020 - 174
Figure 25 Causes of Cancer Pain - 176
Figure 26 Burn Pain Management Approach - 183
Figure 27 Health Expenditures as a Percentage of GDP, by Select Country, 19802015 (%) - 188
Figure 28 Global Market for Pain Management, by Region, 20142022 ($ Millions) - 193
Figure 29 Pain Management Drug Pipeline, by Development Status (Number) - 210
Figure 30 Pain Management Drug Pipeline, by Primary Indication (Number) - 211
Figure 31 Pain Management Devices in Development, by Development Status (%) - 213
Figure 32 Shares of U.S. Patents on Pain Technologies, by Three-Year Date Range, Jan. 2000-March 2017
(%) - 215
Figure 33 Shares of U.S. Patents on Pain Technologies, by Abstract Description (%) - 216
Figure 34 Patent Shares of Pain Technologies (%) - 221
Figure 35 Global Market for Pain Management Pharmaceuticals, by Actual and Projected Brand vs.
Generic Sales Performance, 20122022 ($ Millions) - 228
Figure 36 Distribution of Pain-related Clinical Trials for All Ages, by Region, 2017 (%) - 231
Figure 37 Distribution of Pain-related Clinical Trials for Pediatrics, by Region, 2017 (%) - 232
Figure 38 Global Market for Pain Management, 20152022 ($ Millions) - 237
Figure 39 Global Market for Pain Management, by Major Type, 20142022 ($ Millions) - 239
Figure 40 Global Market for Pain Management, by Application, 20142022 ($ Millions) - 241
Figure 41 Global Market for Pain Management, by Region, 20142022 ($ Millions) - 242

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